Publications

Below are some of our selected publications, for a full list please click here.

RHBDL2 and Orai1 

We performed a bioinformatics-led cell biological screen to identify new substrates for the rhomboid protease RHBDL2. It led to the discovery that RHBDL2 recognises a calcium channel called Orai1 when it is inappropriately activated, and cleaves it to turn it off and thereby control downstream signalling. 

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iRhom2 and ADAM17

We dissected the molecular mechanisms underlying the release of important signalling molecules such as TNF and EGF-like ligands. We revealed that phosphorylation of iRhom2 controls the cell surface sheddase activity of the protease TACE/ADAM17.

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E-cadherin cleavage and tumorigenesis

We noted that during oncogene-driven single cell extrusion from a wild type epithelial monolayer, the adherens junction protein E-cadherin was cleaved. This led us to generate an artificially cleavable form of E-cadherin and show that its cleavage is sufficient to drive epithelial extrusion.

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Secretase rhomboid proteases

We wrote a review of what is (was!) known about rhomboid intramembrane proteases in the mammalian secretory pathway – highlighting their known substrates and forms of regulation.  

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